Applications must satisfy the regulatory authorities that the activity can be undertaken in conditions which are safe for humans and the environment.The prescribed conditions include the provision of risk assessments in relation to human health and safety and environmental protection; the establishment of a local safety committee to advise on risk assessments; classification of all activities into one of four categories related to the degree of risk; notification to the competent authority of an intention to use premises for genetic modification for the first time; notification to the competent authority of individual activities other than those defined as of no or negligible risk, and the preparation of an emergency plan for any reasonably foreseeable accident.