These include:The SCoRe and SEEKIT initiatives which support collaborative,pre-competitive R&D, jointly undertaken between SMEs and public sector sciencebase as well as enhancing public sector research organisations’ ability to workwith business;The highly successful R&D grants under SMART/SPUR/SPURplus aimed at small and medium sized enterprises, researchers and prospective entrepreneurs,which are now at record levels;The Proof of Conceptfund of £40 million fills a funding gap aimed at a pre-development conceptual phaseof high risk projects;The Scottish Co-investment Fund (£45 million) and ScottishProposal Assistance Fund (SPAF) provide additional sources of assistance; The Scottish Higher Education Funding Council has establisheda Knowledge Transfer Grant which will total at least £12 million in 2005-06, doublethe level in 2002-03, andR&D plus designed to actively support large companiesengaged in new and innovative research aimed at developing products with potentialfor global commercial success.Complementaryto these programmes is the establishment by Scottish Enterprise of three IntermediaryTechnology Institutes (ITIs).