HTBS Comments provide advice to NHSScotland on the applicability of the National Institute for Clinical Excellence (NICE) Technology Appraisal Guidance in the light of the contextual differences between Scotland and England and Wales in terms of epidemiology, that is the frequency, distribution and stage at presentation of a disease, the structure and provision of services in Scotland and any other appropriate issue such as rurality issues and predicted uptake.To fulfil this role, HTBS seeks evidence from Scottish experts about these contextual differences and the information in the NICE Assessment Report, and consults with NICE for clarification as necessary.