That the Parliament congratulates researchers at the University of Dundee’s MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) and the School of Medicine on a significant breakthrough in Parkinson’s disease research; understands that the team, supported by the Michael J. Fox Foundation, Medical Research Council, Wellcome Trust and EMBO, identified a new mechanism involving the HRI enzyme that could prevent the build-up of damaged mitochondria in brain cells, a major cause of Parkinson’s-related neurodegeneration; further understands that this research builds on more than two decades of work on the PINK1 and Parkin genes and has uncovered a promising therapeutic strategy that may enhance mitochondrial repair and protect against brain cell loss; welcomes reports that drugs, such as ISRIB, previously developed for other conditions, could be rapidly repurposed for clinical trials in Parkinson’s; acknowledges the leadership of Professor Miratul Muqit and the contribution of Dr Ian Ganley, Dr Adrien Rousseau and Dr Glenn Masson, and commends the University of Dundee for what it sees as its continued excellence in pioneering medical research, which, it believes, has the potential to transform the lives of those living with Parkinson’s and related brain disorders.
Supported by:
Jeremy Balfour, Colin Beattie, Miles Briggs, Tim Eagle, Annabelle Ewing, Kenneth Gibson, Dr Pam Gosal MBE, Bill Kidd, Monica Lennon, Liam McArthur, Stuart McMillan, Paul Sweeney, Brian Whittle